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Structure Elucidation and Antibacterial Activity of New Fungal Metabolites of Sclareol
Author(s) -
Choudhary M. Iqbal,
Siddiqui Zafar Ali,
Hussain Samreen
Publication year - 2006
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200690007
Subject(s) - chemistry , bacillus subtilis , diterpene , antibacterial activity , transformation (genetics) , fermentation , rhizopus , stereochemistry , fusarium , terpene , food science , bacteria , botany , biochemistry , biology , gene , genetics
The transformation of the antibacterial diterpene sclareol ( 1 ) by two different fungal strains was investigated ( Scheme ). In the presence of Rhizopus stolonifer , (3 β )‐3‐hydroxysclareol ( 2 ), 18‐hydroxysclareol ( 3 ), (6 α )‐6,18‐dihydroxysclareol ( 4 ), and (11 S )‐11,18‐dihydroxysclareol ( 5 ) were formed. Fermentation of 1 with Fusarium lini afforded (1 β )‐1‐hydroxysclareol ( 6 ) and (12 S )‐12‐hydroxysclareol ( 7 ). Compounds 4 – 7 were identified as new compounds, and some of them were active against Bacillus subtilis ( Table 3 ).