Structure Elucidation and Antibacterial Activity of New Fungal Metabolites of Sclareol | Zendy

Choudhary M. Iqbal | Zendy; Siddiqui Zafar Ali | Zendy; Hussain Samreen | Zendy

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Structure Elucidation and Antibacterial Activity of New Fungal Metabolites of Sclareol

Author(s) -

Choudhary M. Iqbal,

Siddiqui Zafar Ali,

Hussain Samreen

Publication year - 2006

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200690007

Subject(s) - chemistry , bacillus subtilis , diterpene , antibacterial activity , transformation (genetics) , fermentation , rhizopus , stereochemistry , fusarium , terpene , food science , bacteria , botany , biochemistry , biology , gene , genetics

The transformation of the antibacterial diterpene sclareol ( 1 ) by two different fungal strains was investigated ( Scheme ). In the presence of Rhizopus stolonifer , (3 β )‐3‐hydroxysclareol ( 2 ), 18‐hydroxysclareol ( 3 ), (6 α )‐6,18‐dihydroxysclareol ( 4 ), and (11 S )‐11,18‐dihydroxysclareol ( 5 ) were formed. Fermentation of 1 with Fusarium lini afforded (1 β )‐1‐hydroxysclareol ( 6 ) and (12 S )‐12‐hydroxysclareol ( 7 ). Compounds 4 – 7 were identified as new compounds, and some of them were active against Bacillus subtilis ( Table 3 ).

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