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Trichotomoside: A New Antioxidative Phenylpropanoid Glycoside from Clerodendron trichotomum
Author(s) -
Chae Sungwook,
Kang Kyoung Ah,
Kim Ju Sun,
Hyun Jin Won,
Kang Sam Sik
Publication year - 2006
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200690005
Subject(s) - chemistry , dpph , scavenging , phenylpropanoid , glycoside , antioxidant , reactive oxygen species , stereochemistry , botany , biochemistry , biology , biosynthesis , enzyme
The structure and antioxidant properties of a new natural glycoside, trichotomoside ( 1 ), isolated from Clerodendron trichotomum , were investigated. Trichotomoside was identified as 2‐(3‐hydroxy‐4‐methoxyphenyl)ethyl 3‐ O ‐(2,3‐di‐ O ‐acetyl‐ α ‐ L ‐rhamnopyranosyl)‐4‐ O ‐[(2 E )‐3‐(3‐hydroxy‐4‐methoxyphenyl)prop‐2‐enoyl]‐ β ‐ D ‐glucopyranoside. The compound was active towards intracellular reactive oxygen species (ROS) and exhibited DPPH‐radical‐scavenging effects. The radical‐scavenging activity of 1 was found to protect the viability of Chinese hamster lung fibroblasts (V79‐4 cells) exposed to H 2 O 2 and γ ‐irradiation.
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