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A Pair of Novel Cytotoxic Polyprenylated Xanthone Epimers from Gamboges
Author(s) -
Han QuanBin,
Yang Ling,
Wang YuLin,
Qiao ChunFeng,
Song JingZheng,
Sun HanDong,
Xu HongXi
Publication year - 2006
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200690000
Subject(s) - chemistry , xanthone , epimer , stereochemistry , k562 cells , biochemistry , cell
Two new polyprenylated xanthone epimers were isolated from gamboges of Garcinia hanburyi , and identified by detailed spectroscopic analysis as 30‐hydroxygambogic acid ( 2a ) and its (2 S )‐epimer 30‐hydroxyepigambogic acid ( 2b ). Both compounds exhibited significant cytotoxicities against the human leukemia K562/S and the corresponding doxorubicin‐resistant K562/R cell lines ( Table 2 ).
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