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Synthesis and Biological Evaluation of Novel Compounds Related to 1‐Arylnaphthalene Lignans and Isoquinolines
Author(s) -
Ding Hongxia,
Lu Wei,
Li Haibo,
Yang Leixiang,
Zhang Qijun,
Zhou Changxin,
Wu Xiumei,
Baudoin Olivier,
Cai Junchao,
Guéritte Françoise,
Zhao Yu
Publication year - 2005
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200590092
Subject(s) - isoquinoline , hela , chemistry , lignan , stereochemistry , combinatorial chemistry , in vitro , biochemistry
Novel compounds designed as hybrids of 1‐arylnaphthalene lignans with isoquinoline alkaloids were prepared and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC‐3, CNE, BEL‐7404, and KB. Some of the synthetic compounds exhibited their IC 50 values on selected cell lines at 10 −6 M scale. The preliminary CoMFA molecular‐modelling studies of these synthetic analogues were also performed.