Antileishmanial Physalins from  Physalis minima | Zendy

Choudhary M. Iqbal | Zendy; Yousaf Sammer | Zendy; Ahmed Shakil | Zendy; Yasmeen Kauser | Zendy

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Antileishmanial Physalins from Physalis minima

Author(s) -

Choudhary M. Iqbal,

Yousaf Sammer,

Ahmed Shakil,

Yasmeen Kauser

Publication year - 2005

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200590086

Subject(s) - physalis , chemistry , withanolide , maxima and minima , in vitro , stereochemistry , leishmania , botany , biochemistry , biology , mathematics , medicine , mathematical analysis , alternative medicine , pathology , withania somnifera , parasite hosting , world wide web , computer science

Three new physalins ( 1 – 3 ) and a new withanolide 7 have been isolated from the whole plant of Physalis minima , along with three known physalins: physalin H ( 4 ), isophysalin B ( 5 ), and 5 β ,6 β ‐epoxyphysalin B ( 6 ). Their structures were deduced on the basis of in‐depth spectroscopic analyses. Compounds 1 – 6 showed significant in vitro leishmanicidal activities (0.92–19.4 μg/ml) against promastigotes of Leishmania major.

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