Premium
Antileishmanial Physalins from Physalis minima
Author(s) -
Choudhary M. Iqbal,
Yousaf Sammer,
Ahmed Shakil,
Yasmeen Kauser
Publication year - 2005
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200590086
Subject(s) - physalis , chemistry , withanolide , maxima and minima , in vitro , stereochemistry , leishmania , botany , biochemistry , biology , mathematics , medicine , mathematical analysis , alternative medicine , pathology , withania somnifera , parasite hosting , world wide web , computer science
Three new physalins ( 1 – 3 ) and a new withanolide 7 have been isolated from the whole plant of Physalis minima , along with three known physalins: physalin H ( 4 ), isophysalin B ( 5 ), and 5 β ,6 β ‐epoxyphysalin B ( 6 ). Their structures were deduced on the basis of in‐depth spectroscopic analyses. Compounds 1 – 6 showed significant in vitro leishmanicidal activities (0.92–19.4 μg/ml) against promastigotes of Leishmania major.