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Abietane Diterpenoids from the Roots of some Mexican Salvia Species (Labiatae): Chemical Diversity, Phytogeographical Significance, and Cytotoxic Activity
Author(s) -
Esquivel Baldomero,
Sánchez Ana Adela,
Vergara Fredd,
Matus Wilber,
HernandezOrtega Simón,
RamírezApan M. Teresa
Publication year - 2005
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200590051
Subject(s) - abietane , terpene , chemistry , subgenus , stereochemistry , terpenoid , cytotoxic t cell , cancer cell lines , salvia , genus , botany , biology , biochemistry , cancer , cancer cell , genetics , in vitro
From the roots of some Mexican Salvia species, classified in subgenus Jungia , several diterpenoids belonging to abietane ( i.e. , 3 – 7 ), salvifolane (9→20,10→6)‐diabeoabietane) ( i.e. , 2 ), and totarane ( i.e. , 10 ) carbocyclic skeletons were isolated together with two 20‐nor‐ and one 6,7‐secoabietane derivatives, 1 and 9 , and 8 , respectively. While compounds 2 – 10 were previously known from different sources, compound 1 is a new 20‐norabietane derivative, whose structure was deduced by spectroscopic means and confirmed by X‐ray‐diffraction analysis. The phytogeographical significance of the distribution of 20‐norabietanic diterpenoids in the genus suggested an evolutionary link between the Chinese and New‐World Salvias. Compounds 2 and 8 were tested for cell‐growth inhibition activity against several human cancer cell lines and human normal lymphocytes, while 2 showed a moderate cytotoxic activity, 8 exhibited a moderate yet selective activity against leukemia cell line.