Premium
Fungal Metabolites of ( E )‐Guggulsterone and Their Antibacterial and Radical‐Scavenging Activities
Author(s) -
Choudhary M. Iqbal,
Shah S. Adnan Ali,
Sami Amtul,
Ajaz Asma,
Shaheen Farzana
Publication year - 2005
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200590033
Subject(s) - chemistry , gibberella fujikuroi , scavenging , acetylation , fusarium , stereochemistry , transformation (genetics) , biochemistry , botany , antioxidant , biology , gene
Fungal transformation of ( E )‐guggulsterone (=(17 E )‐pregna‐4,17‐diene‐3,16‐dione; 1 ) by Rhizopus stolonifer, Fusarium lini, Cunninghamella elegans , or Gibberella fujikuroi afforded ten hydroxylated metabolites ( 2 – 11 ; Scheme ), which were fully characterized. Compounds 4 – 11 have not been described yet. Some of these novel hydroxylated metabolites, as well as acetylated derivatives thereof, exhibited significant antibacterial and radical‐scavenging activities ( Table 3 ).