Fungal Metabolites of ( E )‐Guggulsterone and Their Antibacterial and Radical‐Scavenging Activities | Zendy

Choudhary M. Iqbal | Zendy; Shah S. Adnan Ali | Zendy; Sami Amtul | Zendy; Ajaz Asma | Zendy; Shaheen Farzana | Zendy

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Fungal Metabolites of ( E )‐Guggulsterone and Their Antibacterial and Radical‐Scavenging Activities

Author(s) -

Choudhary M. Iqbal,

Shah S. Adnan Ali,

Sami Amtul,

Ajaz Asma,

Shaheen Farzana

Publication year - 2005

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200590033

Subject(s) - chemistry , gibberella fujikuroi , scavenging , acetylation , fusarium , stereochemistry , transformation (genetics) , biochemistry , botany , antioxidant , biology , gene

Fungal transformation of ( E )‐guggulsterone (=(17 E )‐pregna‐4,17‐diene‐3,16‐dione; 1 ) by Rhizopus stolonifer, Fusarium lini, Cunninghamella elegans , or Gibberella fujikuroi afforded ten hydroxylated metabolites ( 2 – 11 ; Scheme ), which were fully characterized. Compounds 4 – 11 have not been described yet. Some of these novel hydroxylated metabolites, as well as acetylated derivatives thereof, exhibited significant antibacterial and radical‐scavenging activities ( Table 3 ).

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