Formation of a New Oxidative Metabolite from Kobophenol A by Human Intestinal Bacterium  Klebsiella pneumoniae | Zendy

Liang Gaolin | Zendy; Qian Lisheng | Zendy; Cui Yiling | Zendy; Hu Changqi | Zendy

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Formation of a New Oxidative Metabolite from Kobophenol A by Human Intestinal Bacterium Klebsiella pneumoniae

Author(s) -

Liang Gaolin,

Qian Lisheng,

Cui Yiling,

Hu Changqi

Publication year - 2005

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200590031

Subject(s) - metabolite , chemistry , oxidative phosphorylation , metabolic pathway , klebsiella pneumoniae , feces , mass spectrometry , metabolism , high performance liquid chromatography , human feces , chromatography , in vitro , metabolomics , bacteria , biochemistry , microbiology and biotechnology , escherichia coli , biology , genetics , gene

During our studies on the metabolism of kobophenol A ( 1 ) in rats, we had isolated, purified, and identified the main new oxidative metabolite of 1 , koboquinone A ( 2 ) from rats' feces. To elucidate the metabolic pathway of 1 in rats, we conducted the in vitro metabolic experiments of 1 by human intestinal bacteria and found that Klebsiella pneumoniae produced appreciable amounts of 2 . This was verified by means of high performance liquid chromatography mass/mass spectrometry (HPLC/MS/MS) analysis.

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