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Antitumor‐Promoting Effects of New Sesquiterpenes from Crossopetalum tonduzii
Author(s) -
Mendoza Cristina R.,
Jiménez Ignacio A.,
Tokuda Harukuni,
Kushida Hiroyuki,
Bazzocchi Isabel L.
Publication year - 2005
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200590011
Subject(s) - chemistry , stereochemistry , traditional medicine , pharmacology , medicine
Seven new sesquiterpenes ( 1 – 7 ) with a ‘dihydro‐ β ‐agarofuran’ (=5,11‐epoxy‐5 β ,10 α ‐eudesmane) skeleton were isolated from Crossopetalum tonduzii. Their structures were elucidated spectroscopically, especially by means of homo‐ and heteronuclear NMR correlation (COSY, ROESY, HSQC, and HMBC). The absolute configurations of the new compounds were determined by circular dichroism (CD) studies and by chemical correlations via the derivatives 8 – 11 . The new compounds showed moderate antitumor‐promoting effects with respect to the activation of the Epstein–Barr virus early antigen (EBV‐EA).