Antitumor‐Promoting Effects of New Sesquiterpenes from  Crossopetalum tonduzii | Zendy

Mendoza Cristina R. | Zendy; Jiménez Ignacio A. | Zendy; Tokuda Harukuni | Zendy; Kushida Hiroyuki | Zendy; Bazzocchi Isabel L. | Zendy

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Antitumor‐Promoting Effects of New Sesquiterpenes from Crossopetalum tonduzii

Author(s) -

Mendoza Cristina R.,

Jiménez Ignacio A.,

Tokuda Harukuni,

Kushida Hiroyuki,

Bazzocchi Isabel L.

Publication year - 2005

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200590011

Subject(s) - chemistry , stereochemistry , traditional medicine , pharmacology , medicine

Seven new sesquiterpenes ( 1 – 7 ) with a ‘dihydro‐ β ‐agarofuran’ (=5,11‐epoxy‐5 β ,10 α ‐eudesmane) skeleton were isolated from Crossopetalum tonduzii. Their structures were elucidated spectroscopically, especially by means of homo‐ and heteronuclear NMR correlation (COSY, ROESY, HSQC, and HMBC). The absolute configurations of the new compounds were determined by circular dichroism (CD) studies and by chemical correlations via the derivatives 8 – 11 . The new compounds showed moderate antitumor‐promoting effects with respect to the activation of the Epstein–Barr virus early antigen (EBV‐EA).

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