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Antiplasmodial Activity of Naphthoquinones Related to Lapachol and β ‐Lapachone
Author(s) -
PérezSacau Elisa,
EstévezBraun Ana,
Ravelo Ángel G.,
Gutiérrez Yapu David,
Giménez Turba Alberto
Publication year - 2005
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200590009
Subject(s) - chemistry , naphthoquinone , in vitro , plasmodium falciparum , 1,4 naphthoquinone , ic50 , stereochemistry , pharmacology , traditional medicine , biochemistry , organic chemistry , malaria , biology , immunology , medicine
The in vitro antiplasmodial activity of 26 naphthoquinone derivatives related to the natural lapachol ( 1 ) and β ‐lapachone ( 2 ) was tested. Ten of these derivatives are reported for the first time. The evaluation was performed on cultures of F32 strain of Plasmodium falciparum , and some derivatives displayed attractive in vitro activities ( IC 50 <10 μ M ). Based on these results, some structureactivity relationships have been determined.