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New Gemacranolides from Eupatorium hualienense
Author(s) -
Shen YaChing,
Jang JiunYang,
Taha Khalil Ashraf,
Chai Chiang Lien
Publication year - 2005
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200590007
Subject(s) - chemistry , phytochemical , stereochemistry , chronic myelogenous leukemia , k562 cells , sesquiterpene , leukemia , cancer cell lines , cancer , biochemistry , cell , cancer cell , biology , immunology , genetics
Phytochemical investigation of Eupatorium hualienense (C. H. Ou , S. W. Chung , C. I. Peng ) has resulted in the isolation of the new sesquiterpene lactones 1 – 5 , named eupahualins A – E , along with the known heliangolide eupasimplicin B ( 6 ). The structures of the isolated compounds were established through detailed spectral analyses, especially by means of 2D‐NMR techniques. Compounds 1 – 4 and 6 showed significant activities against cell lines of human chronic myelogenous leukemia (K562) and human bone cancer (U2OS).