New Gemacranolides from  Eupatorium hualienense | Zendy

Shen YaChing | Zendy; Jang JiunYang | Zendy; Taha Khalil Ashraf | Zendy; Chai Chiang Lien | Zendy

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New Gemacranolides from Eupatorium hualienense

Author(s) -

Shen YaChing,

Jang JiunYang,

Taha Khalil Ashraf,

Chai Chiang Lien

Publication year - 2005

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200590007

Subject(s) - chemistry , phytochemical , stereochemistry , chronic myelogenous leukemia , k562 cells , sesquiterpene , leukemia , cancer cell lines , cancer , biochemistry , cell , cancer cell , biology , immunology , genetics

Phytochemical investigation of Eupatorium hualienense (C. H. Ou , S. W. Chung , C. I. Peng ) has resulted in the isolation of the new sesquiterpene lactones 1 – 5 , named eupahualins A – E , along with the known heliangolide eupasimplicin B ( 6 ). The structures of the isolated compounds were established through detailed spectral analyses, especially by means of 2D‐NMR techniques. Compounds 1 – 4 and 6 showed significant activities against cell lines of human chronic myelogenous leukemia (K562) and human bone cancer (U2OS).

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