Premium
Pyrimidine as Constituent of Natural Biologically Active Compounds
Author(s) -
Lagoja Irene M.
Publication year - 2005
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200490173
Subject(s) - pyrimidine , chemistry , pyrimidine analogue , pyrimidine metabolism , alkylation , biological activity , combinatorial chemistry , biochemistry , stereochemistry , purine , catalysis , in vitro , enzyme
This review describes the various manifestations of the pyrimidine system (alkylated, glycosylated, benzo‐annelated.). These comprise pyrimidine nucleosides as well as alkaloids and antibiotics – some of them have been discovered and isolated from natural sources already long time ago, others have been reported very recently. A short overview on pyrimidine syntheses (prebiotic synthesis, biosynthesis, and metabolism) is given. The biological activities of most of the pyrimidine analogs are briefly described, and, in some cases, syntheses are formulated.