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A New Destruxin as Inhibitor of Vacuolar‐Type H + ‐ATPase of Saccharomyces cerevisiae
Author(s) -
Vázquez María J.,
Albarrán María I.,
Espada Alfonso,
RiveraSagredo Alfonso,
Díez Emilio,
HuesoRodríguez Juan A.
Publication year - 2005
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200490163
Subject(s) - saccharomyces cerevisiae , chemistry , atpase , structural isomer , biochemistry , metarhizium anisopliae , fungus , stereochemistry , nuclear magnetic resonance spectroscopy , enzyme , yeast , biology , botany , conidium
In the course of our screening efforts to discover small molecules as selective inhibitors of vacuolar‐type H + ‐ATPase of Saccharomyces cerevisiae , we have identified eight active destruxins, 1 – 8 , from the fungus Metarhizium anisopliae. The structures were elucidated by extensive 1D‐ and 2D‐NMR spectroscopy, and MS spectrometry. One of these compounds, 8 , a regioisomer of chlorohydrin destruxin E ( 7 ), is a new destruxin.