A New Destruxin as Inhibitor of Vacuolar‐Type H + ‐ATPase of  Saccharomyces cerevisiae | Zendy

Vázquez María J. | Zendy; Albarrán María I. | Zendy; Espada Alfonso | Zendy; RiveraSagredo Alfonso | Zendy; Díez Emilio | Zendy; HuesoRodríguez Juan A. | Zendy

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A New Destruxin as Inhibitor of Vacuolar‐Type H + ‐ATPase of Saccharomyces cerevisiae

Author(s) -

Vázquez María J.,

Albarrán María I.,

Espada Alfonso,

RiveraSagredo Alfonso,

Díez Emilio,

HuesoRodríguez Juan A.

Publication year - 2005

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200490163

Subject(s) - saccharomyces cerevisiae , chemistry , atpase , structural isomer , biochemistry , metarhizium anisopliae , fungus , stereochemistry , nuclear magnetic resonance spectroscopy , enzyme , yeast , biology , botany , conidium

In the course of our screening efforts to discover small molecules as selective inhibitors of vacuolar‐type H + ‐ATPase of Saccharomyces cerevisiae , we have identified eight active destruxins, 1 – 8 , from the fungus Metarhizium anisopliae. The structures were elucidated by extensive 1D‐ and 2D‐NMR spectroscopy, and MS spectrometry. One of these compounds, 8 , a regioisomer of chlorohydrin destruxin E ( 7 ), is a new destruxin.

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