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Novel Antibacterial Diterpenoids from Larix chinensis B eissn
Author(s) -
Xue JunJuan,
Fan ChengQi,
Dong Lei,
Yang ShengPing,
Yue JianMin
Publication year - 2004
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200490128
Subject(s) - chemistry , staphylococcus epidermidis , staphylococcus aureus , labdane , bark (sound) , antibacterial activity , diterpene , stereochemistry , terpenoid , terpene , bacteria , biology , ecology , genetics
Two novel labdane‐type diterpenoids, butanedioic acid mono[(13 S )‐13‐hydroxylabda‐8(17),14‐dien‐19‐yl] ester ( 1 ) and butanedioic acid bis[(13 S )‐13‐hydroxylabda‐8(17),14‐dien‐19‐yl] ester ( 2 ), along with the eleven known diterpenoids 3 – 13 and three other known compounds, were isolated from the bark of Larix chinensis. Their structures were elucidated both spectroscopically and chemically. The major diterpenoids 1 – 9, 11 , and 13 , as well as the very abundant phenolic compound 16 , were subjected to antibacterial and cytotoxic bioassays. Compounds 7 and 9 showed remarkable in vitro inhibition of Staphylococcus aureus and S. epidermidis ( MIC =37–73 μ M ).