Premium
Exploratory Studies to Investigate a Linked Prebiotic Origin of RNA and Coded Peptides. 3rd Communication
Author(s) -
Ace Karl,
Sutherland John D.
Publication year - 2004
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200490126
Subject(s) - chemistry , prebiotic , rna , computational biology , biochemistry , gene , biology
The potentially prebiotic synthesis of pyrimidine ribo nucleotides by stepwise nucleobase assembly on arabinose‐3‐phosphate derivatives has been demonstrated in previous work. The generation of xylose‐2‐phosphate derivatives by aldolisation, and the behaviour of these compounds under the conditions of pyrimidine nucleobase assembly have also been described. In this paper, the scope for generation of purine nucleotides via 3,3′‐anhydro‐ xylo ‐nucleotides is investigated. In neutral D 2 O solution, the potential intermediate 47 ( Schemes 6 and 8 ) undergoes HC(2)→DC(2) exchange, but no appreciable reaction with cyanide or cyanamide occurs. The exchange chemistry expands options for purine nucleobase assembly on sugar phosphate scaffolds.