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Antimicrobial Activity of Hydrophobic Xanthones from Cudrania cochinchinensis against Bacillus subtilis and Methicillin‐Resistant Staphylococcus aureus
Author(s) -
Fukai Toshio,
Oku Yukio,
Hou AiJun,
Yonekawa Makiko,
Terada Sumio
Publication year - 2004
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200490101
Subject(s) - micrococcus luteus , bacillus subtilis , staphylococcus aureus , antimicrobial , chemistry , moraceae , microbiology and biotechnology , antibacterial activity , methicillin resistant staphylococcus aureus , traditional medicine , bacteria , biology , organic chemistry , medicine , genetics
Ten xanthones with one or two isoprenoid groups and a prenylated benzophenone isolated from roots of Cudrania cochinchinensis (Moraceae) were tested for their antimicrobial activities against Bacillus subtilis and methicillin‐resistant Staphylococcus aureus (MRSA). Among these compounds, gerontoxanthone H exhibited considerable antibacterial activity against B. subtilis ( MIC =1.56 μg/ml). Four xanthones, gerontoxanthone I, toxyloxanthone C, cudraxanthone S, and 1,3,7‐trihydroxy‐2‐prenylxanthone, showed weak antibacterial activity against the bacterium ( MIC s=3.13–6.25 μg/ml). These compounds also exhibited similar MIC values against methicillin‐sensitive S. aureus , MRSAs, and Micrococcus luteus.