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Antifeedant C 20 Diterpene Alkaloids
Author(s) -
GonzálezColoma Azucena,
Reina Matías,
Guadaño Ana,
MartínezDíaz Rafael,
Díaz Jesús G.,
GarcíaRodriguez Juan,
Alva Allenger,
Grandez Maritza
Publication year - 2004
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200490095
Subject(s) - spodoptera littoralis , leptinotarsa , diterpene , terpenoid , ec50 , spodoptera , chemistry , insect , sf9 , stereochemistry , botany , larva , biology , in vitro , noctuidae , biochemistry , gene , recombinant dna
We have tested the insect antifeedant and toxic activity of 21 C 20 diterpenoid alkaloids on Spodoptera littoralis and Leptinotarsa decemlineata. The antifeedant effects of the test compounds were structure‐ and species‐dependent. The most active antifeedants to L. decemlineata and S. littoralis were the rearranged form of hetisine ( 20 ; EC 50 =1.7 μg/cm 2 ) and 19‐oxodihydroatisine ( 9 ; EC 50 =0.1 μg/cm 2 ), resp. Glandulosine ( 8 ) moderately affected orally injected S. littoralis larvae. A few compounds (13‐oxocardiopetamine ( 4 ), 9 , and atisinium chloride ( 13 )) had cytotoxic effects to insect‐derived Sf9 cells with varying degrees of selectivity with respect to mammalian CHO cells. Compounds 4 and 15,22‐ O ‐diacetyl‐19‐oxodihydroatisine ( 10 ) increased Trypanosoma cruzi mortality. Our results support the plant protective role of C 20 diterpenoid alkaloids and open a new field for parasite control strategies.