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Microwave‐Induced Enzyme‐Catalyzed Chemoselective Reduction of Organic Azides
Author(s) -
Mazumder Sharbani,
Laskar Dhrubojyoti D.,
Prajapati Dipak,
Roy Manoj K.
Publication year - 2004
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200490074
Subject(s) - chemoselectivity , chemistry , lipase , microwave irradiation , catalysis , azide , microwave , organic synthesis , enzyme , organic chemistry , biocatalysis , combinatorial chemistry , reaction mechanism , physics , quantum mechanics
A lipase enzyme, suspended in organic media along with organic azides and irradiated under microwaves, enhances the reaction rate over thermal heating and affords the corresponding amines in high yields. The present biocatalytic method employing lipase is a significant development with remarkable regio‐ and chemoselectivity under microwave irradiation in organic media with excellent yields for the reduction of azide functionality.