Cancer Chemopreventive Activity of Serratane‐Type Triterpenoids from  Picea jezoensis | Zendy

Tanaka Reiko | Zendy; Minami Toshifumi | Zendy; Ishikawa Yohei | Zendy; Tokuda Harukuni | Zendy; Matsunaga Shunyo | Zendy

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Cancer Chemopreventive Activity of Serratane‐Type Triterpenoids from Picea jezoensis

Author(s) -

Tanaka Reiko,

Minami Toshifumi,

Ishikawa Yohei,

Tokuda Harukuni,

Matsunaga Shunyo

Publication year - 2004

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200490070

Subject(s) - chemistry , dmba , oleanolic acid , carcinogenesis , pinaceae , triterpene , botany , biochemistry , pinus <genus> , biology , pathology , gene , medicine , alternative medicine

To search for cancer chemopreventive agents from natural sources, 13 α ,14 α ‐epoxy‐21 α ‐methoxyserratan‐3‐one, 21 α ‐methoxyserrat‐13‐en‐3‐one, and 21 α ‐hydroxy‐3 β ‐methoxyserrat‐14‐en‐30‐al isolated from the cuticle of Picea jezoensis ( Sieb. et Zucc. ) Carr. var. jezoensis (Pinaceae) were investigated for inhibitory effects in a two‐stage mouse skin carcinogenesis test on mouse skin with 7,12‐dimethylbenz[ a ]anthracene (DMBA) as initiator and 12‐ O ‐tetradecanoylphorbol‐13‐acetate (TPA) as promoter. 21 α ‐hydroxy‐3 β ‐methoxyserrat‐14‐en‐30‐al and 13 α ,14 α ‐epoxy‐21 α ‐methoxyserratan‐3‐one were found to exhibit strong antitumor‐promoting activities in the in vivo carcinogenesis test.

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