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Synthesis, Spectral Properties, and Antitumor Activity of a New Axially Substituted Phthalocyanine Complex of Zirconium(IV) with Citric Acid
Author(s) -
Tomachynski Larisa A.,
Chernii Victor Y.,
Gorbenko Helena N.,
Filonenko Valeriy V.,
Volkov Sergey V.
Publication year - 2004
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200490068
Subject(s) - chemistry , citric acid , zirconium , phthalocyanine , axial symmetry , spectral properties , inorganic chemistry , combinatorial chemistry , organic chemistry , computational chemistry , structural engineering , engineering
The new axially substituted phthalocyanine (pc) complex of zirconium(IV) with citric acid is reported. It has been shown that the replacement of two Cl‐atoms with two citric acid fragments takes place as the result of the reaction between [ZrCl 2 (pc)] and citric acid. The complex [Zr(citrate) 2 (pc)] was formed. The spectroscopic properties of the synthesized compound in DMSO, RPMI 1640 medium with and without fetal calf serum (FCS), H 2 O, and buffer ( Tris ) solutions have been described. Antitumor activity of this compound has been studied. The cytostatic activity was observed in the concentration range of 6.1–9.0×10 9 molecules [Zr(citrate) 2 (pc)]/cell and occurred in 4–6 h after treatment with [Zr(citrate) 2 (pc)] solution.