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Copper(II) Complexes Containing N,N‐Donor Ligands and Dipeptides Act as Hydrolytic DNA‐Cleavage Agents
Author(s) -
Reddy Pulimamidi R.,
Rao Kandibanda S.,
Mohan Sepuru K.
Publication year - 2004
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200490066
Subject(s) - chemistry , cleavage (geology) , ethylenediamine , dna , combinatorial chemistry , copper , fluorescence , molecule , stereochemistry , metal , small molecule , biochemistry , inorganic chemistry , organic chemistry , physics , geotechnical engineering , quantum mechanics , fracture (geology) , engineering
Abstract Copper(II) complexes are known to play a significant role in both naturally occurring biological systems and pharmaceutical agents. Recently, Cu II complexes have gained importance in DNA cleavage essential for the development of anticancer drugs and chemotherapeutic agents. Therefore, we have designed small molecules, consisting of a metal ion, N,N‐donor ligands, and dipeptides, to probe their DNA‐cleaving potential. Accordingly, the interaction of Cu II with ethylenediamine, histamine and the dipeptides histidylglycine, histidylalanine, and histidylleucine has been investigated. The binding modes, stabilities, and geometries of these complexes were determined by various physicochemical techniques. Their DNA‐binding abilities were probed by absorption and fluorescence spectroscopy, and their DNA‐cleavage potential was tested by electrophoresis.