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Biologically Active Ibogan and Vallesamine Derivatives from Tabernaemontana divaricata
Author(s) -
Kam TohSeok,
Pang HueyShen,
Choo YeunMun,
Komiyama Kanki
Publication year - 2004
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200490056
Subject(s) - chemistry , cytotoxicity , indole test , stereochemistry , bark (sound) , apocynaceae , epidermoid carcinoma , alkaloid , traditional medicine , cancer cell lines , biological activity , carcinoma , biochemistry , cancer cell , in vitro , cancer , biology , medicine , ecology , genetics
Six new indole alkaloids, viz. , (3 S )‐3‐cyanocoronaridine ( 2 ), (3 S )‐3‐cyanoisovoacangine ( 3 ), conolobine A ( 5 ), conolobine B ( 6 ), conolidine ( 7 ), and (3 R /3 S )‐3‐ethoxyvoacangine ( 8 ), in addition to 36 known ones, were obtained from the stem‐bark extract of the Malayan Tabernaemontana divaricata. The structures were determined by NMR and MS analysis. The CN‐substituted alkaloids showed appreciable cytotoxicity towards the KB human oral epidermoid carcinoma cell‐line.