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A Novel Type of Membranes Based on Cholesteryl Phosphate
Author(s) -
Sedaghat Soheila,
Désaubry Laurent,
Streiff Stéphane,
Ribeiro Nigel,
Michels Bernard,
Nakatani Yoichi,
Ourisson Guy
Publication year - 2004
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200490003
Subject(s) - chemistry , vesicle , amphiphile , phosphate , bilayer , isothermal microcalorimetry , membrane , phospholipid , liposome , biophysics , chromatography , organic chemistry , biochemistry , physics , enthalpy , polymer , quantum mechanics , biology , copolymer
Mixtures of the rigid amphiphile disodium cholesteryl phosphate (DCP) with the non‐phosphorylated diacyl amphiphile dimyristoylglycerol (DMG) give self‐organized systems in a wide range of pH, as demonstrated by differential microcalorimetry. These systems can be closed bilayer vesicles, as shown by optical microscopy ( Nomarski and confocal). Neither DMG nor DCP, taken alone, give vesicles in these conditions but 10% DMG is enough to lead to the formation of vesicles from pH 5.8 to 9.3. These novel self‐organized systems are akin to the classical eucaryotic ones, built on a phosphorylated diacylglycerol and free cholesterol (or analogues), the only difference being the site of the phosphate head‐group.