Premium
Efficacy of FGF‐2 in Periodontal Regeneration in a Case of Severe Intrabony Defect and Furcation Involvement With 15‐Month Follow‐Up
Author(s) -
Takayama Shinichi,
Murakami Shinya
Publication year - 2021
Publication title -
clinical advances in periodontics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.182
H-Index - 2
eISSN - 2163-0097
pISSN - 2573-8046
DOI - 10.1002/cap.10127
Subject(s) - furcation defect , medicine , dentistry , periodontitis , regeneration (biology) , orthodontics , molar , biology , microbiology and biotechnology
Several studies have demonstrated that basic fibroblast growth factor (FGF‐2) is one of the most effective growth factors for periodontal regeneration. The Ministry of Health, Labor and Welfare in Japan have approved 0.3% human recombinant FGF‐2 for periodontal regeneration, and it has been commercially available since 2016. In this case report, a patient was treated with this periodontal regenerative medicine and demonstrated success at 15‐month follow‐up, as confirmed by dental X‐ray and on cone‐beam computed tomography (CBCT). Case Presentation A 42‐year‐old woman with a one by two walled intrabony defect and Class III furcation involvement in tooth #19, and Class II furcation involvement in tooth #18 (lingual) underwent periodontal regenerative surgery with FGF‐2 without any bone graft materials. Favorable clinical and radiographic outcomes were noted 15 months after the procedure. The vertical bone defect in tooth #19 showed a clinical attachment level gain of 8 mm. Moreover, CBCT analysis revealed considerable new bone formation in the Class II furcation involvement in tooth #18 and limited bone formation in the Class III furcation involvement in tooth #19. Conclusions This case report indicates that FGF‐2 showed a positive outcome in terms of periodontal regeneration in a case of one by two wall intrabony defects with Class III furcation involvement. A complete recovery of Class II furcation involvement was observed without artificial bone graft materials.