Open AccessUpregulation of long noncoding RNA TUG1 promotes cervical cancer cell proliferation and migration
Author(s) -
Hu Yingying,
Sun Xiangwei,
Mao Chenchen,
Guo Gangqiang,
Ye Sisi,
Xu Jianfeng,
Zou Ruanmin,
Chen Jun,
Wang Ledan,
Duan Ping,
Xue Xiangyang
Publication year - 2017
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.994
Subject(s) - oncogene , cancer research , carcinogenesis , gene knockdown , downregulation and upregulation , gene silencing , biology , cervical cancer , long non coding rna , cell growth , cancer , metastasis , gene , cell cycle , genetics
Long noncoding RNA s (lnc RNA s), a novel class of transcripts that have critical roles in carcinogenesis and progression, have emerged as important gene expression modulators. Recent evidence indicates that lnc RNA taurine‐upregulated gene 1 ( TUG 1) functions as an oncogene in numerous types of human cancers. However, its function in the development of cervical cancer remains unknown. The aim of this research was to investigate the clinical significance and biological functions of TUG 1 in cervical cancer. TUG 1 was found to be significantly upregulated in cervical cancer tissues and four cervical cancer cell lines by quantitative real‐time polymerase chain reaction ( qRT ‐ PCR ). Elevated TUG 1 expression was correlated with larger tumor size, advanced international federation of gynecology and obstetrics ( FIGO ) stage, poor differentiation, and lymph node metastasis. Furthermore, knockdown of TUG 1 suppressed cell proliferation with activation of apoptosis, in part by regulating the expression of Bcl‐2 and caspase‐3. Silencing of TUG 1 inhibited cell migration and invasion via the progression of epithelial–mesenchymal transition ( EMT ). Taken together, our findings indicate that TUG 1 acts as an oncogene in cervical cancer and may represent a novel therapeutic target.