Open AccessQuercetin suppresses lung cancer growth by targeting Aurora B kinase
Author(s) -
Xingyu Zhu,
Peijie Ma,
Dan Peng,
Youg Wang,
Daojun Wang,
Xinzheng Chen,
Xijun Zhang,
Yangrong Song
Publication year - 2016
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.891
Subject(s) - quercetin , in vivo , lung cancer , a549 cell , cancer research , in vitro , carcinogenesis , cancer cell , kinase , cancer , ex vivo , chemistry , aurora inhibitor , pharmacology , biology , medicine , biochemistry , cell cycle , microbiology and biotechnology , antioxidant
aurora B kinase is highly expressed in several cancer cells and promotes tumorigenesis and progression, and therefore, it is an important target for drug to treat tumors. Quercetin was identified to be an antitumor agent. Herein, we report for the first time that quercetin inhibited aurora B activities by directly binding with aurora B in vitro and in vivo. Ex vivo studies showed that quercetin inhibited aurora B activities in JB 6 Cl41 cells and A549 lung cancer cells. Moreover, knockdown of aurora B in A549 cells decreased their sensitivities to quercetin. In vivo study demonstrated that injection of quercetin in A549 tumor‐bearing mice effectively suppressed cancer growth. The phosphorylation of histone 3 in tumor tissues was also decreased after quercetin treatment. In short, quercetin can suppress growth of lung cancer cells as an aurora B inhibitor both in vitro and in vivo.