Open AccessThe hedgehog pathway in triple‐negative breast cancer
Author(s) -
Habib Joyce G.,
O'Shaughnessy Joyce A.
Publication year - 2016
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.833
Subject(s) - triple negative breast cancer , hedgehog , breast cancer , hedgehog signaling pathway , cancer research , crosstalk , targeted therapy , medicine , stem cell , bioinformatics , signal transduction , cancer , biology , oncology , genetics , physics , optics
Treatment of triple‐negative breast cancer ( TNBC ) remains challenging due to the underlying heterogeneity of this disease coupled with the lack of predictive biomarkers and effective targeted therapies. Intratumoral heterogeneity, particularly enrichment for breast cancer stem cell‐like subpopulations, has emerged as a leading hypothesis for systemic therapy resistance and clinically aggressive course of poor prognosis TNBC . A growing body of literature supports the role of the stem cell renewal Hedgehog (Hh) pathway in breast cancer. Emerging preclinical data also implicate Hh signaling in TNBC pathogenesis. Herein, we review the evidence for a pathophysiologic role of Hh signaling in TNBC and explore mechanisms of crosstalk between the Hh pathway and other key signaling networks as well as their potential implications for Hh‐targeted interventions in TNBC .