Open AccessGenetic variants within micro RNA ‐binding site of RAD51B are associated with risk of cervical cancer in Chinese women
Author(s) -
Hang Dong,
Zhou Wen,
Jia Meiqun,
Wang Lihua,
Zhou Jing,
Yin Yin,
Ma Hongxia,
Hu Zhibin,
Li Ni,
Shen Hongbin
Publication year - 2016
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.797
Subject(s) - cervical cancer , haplotype , allele , cancer , genetics , genotype , oncology , case control study , biology , logistic regression , medicine , genetic predisposition , single nucleotide polymorphism , gene
RAD 51B plays a central role in homologous recombinational repair ( HRR ) of DNA double‐strand breaks ( DSB s), which is important to prevent genomic instability, a hallmark of cancer. Recent studies suggested that common genetic variants of RAD 51B may contribute to cancer susceptibility. In this study, we aimed to investigate whether potentially functional variants within mi RNA ‐binding sites of RAD 51B are associated with risk of cervical cancer. A total of 1486 cervical cancer patients and 1536 cancer‐free controls were enrolled, and two genetic variants, rs963917 (A > G) and rs963918 (T > C), were genotyped in all participants. Using multivariate logistic regression analyses, we found that G allele of rs963917 conferred lower risk of cervical cancer compared to A allele (adjusted OR = 0.89, 95% CI = 0.80–0.99, P = 0.039). Similarly, rs963918 allele C was associated with a decreased risk for cervical cancer compared with allele T (adjusted OR = 0.84, 95% CI = 0.74–0.94, P = 0.004). Haplotype analyses showed that haplotype GC was also correlated with lower risk ( OR = 0.83, 95% CI = 0.73–0.95, P = 0.005) compared with the most common haplotype AT . In summary, our study suggested that mi RNA ‐binding site genetic variants of RAD 51B may modify the susceptibility to cervical cancer, which is important to identify individuals with differential risk for this malignancy and to improve the effectiveness of preventive intervention.