Open AccessCopy‐number variation of MCL1 predicts overall survival of non‐small‐cell lung cancer in a Southern Chinese population
Author(s) -
Yin Jieyun,
Li Yangkai,
Zhao Hao,
Qin Qin,
Li Xiaorong,
Huang Jiao,
Shi Yun,
Gong Shufang,
Liu Li,
Fu Xiangning,
Nie Shaofa,
Wei Sheng
Publication year - 2016
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.774
Subject(s) - copy number variation , biology , lung cancer , oncology , medicine , hazard ratio , gene , population , cancer , biomarker , cancer research , genetics , confidence interval , genome , environmental health
BCL 2L1 and MCL 1 are key anti‐apoptotic genes, and critical for cancer progression. The prognostic values of BCL 2L1 and MCL 1 copy‐number variations ( CNV s) in non‐small‐cell lung cancer ( NSCLC ) remain largely unknown. Somatic CNV s in BCL 2L1 and MCL 1 genes were tested in tumor tissues from 516 NSCLC patients in southern China; afterward, survival analyses were conducted with overall survival ( OS ) as outcome. Additionally, the associations between CNV s and mRNA expression levels were explored using data from 986 NSCLC patients in the Cancer Genome Atlas project. It was found that amplifications of BCL 2L1 and MCL 1 were associated with unfavorable OS of NSCLC , with adjusted hazards ratio of 1.62 (95% confident interval [CI] = 1.10–2.40; P = 0.015) and 1.39 (95% CI = 1.05–1.84; P = 0.020), respectively. Amplifications of MCL 1, but not BCL 2L1, were related with higher mRNA expression levels of corresponding gene, compared with non‐amplifications ( P = 0.005). Interestingly, after incorporating with MCL 1 CNV status, clinical variables (age, sex, TNM stage, and surgical approach) showed an improved discriminatory ability to classify OS (area under curve increased from 72.2% to 74.1%; P = 0.042, DeLong's test). Overall, MCL 1 CNV might be a prognostic biomarker for NSCLC , and additional investigations are needed to validate our findings.