Open AccessHuman polyomaviruses and incidence of cutaneous squamous cell carcinoma in the New Hampshire skin cancer study
Author(s) -
Gossai Anala,
Waterboer Tim,
Hoen Anne G.,
Farzan Shohreh F.,
Nelson Heather H.,
Michel Angelika,
WillhauckFleckenstein Martina,
Christensen Brock C.,
Perry Ann E.,
Pawlita Michael,
Karagas Margaret R.
Publication year - 2016
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.674
Subject(s) - serology , skin cancer , population , odds ratio , immunology , medicine , cancer , serostatus , basal cell carcinoma , biology , case control study , antibody , virus , basal cell , viral load , environmental health
Squamous cell carcinoma ( SCC ) of the skin is a malignancy arising from epithelial keratinocytes. Experimental and epidemiologic evidence raise the possibility that human polyomaviruses ( PyV ) may be associated with the occurrence of SCC . To investigate whether the risk for SCC was associated with PyV infection, seropositivity to 10 PyV types was assessed following diagnosis in a population‐based case–control study conducted in the United States. A total of 253 SCC cases and 460 age group and gender‐matched controls were included. Antibody response against each PyV was measured using a multiplex serology‐based glutathione S‐transferase capture assay of recombinantly expressed VP 1 capsid proteins. Odds ratios ( OR ) for SCC associated with seropositivity to each PyV type were estimated using logistic regression, with adjustment for potentially confounding factors. SCC cases were seropositive for a greater number of PyV s than controls ( P = 0.049). Those who were JC seropositive had increased odds of SCC when compared to those who were JC seronegative ( OR = 1.37, 95% CI : 0.98–1.90), with an increasing trend in SCC risk with increasing quartiles of seroreactivity ( P for trend = 0.04). There were no clear associations between SCC risk and serostatus for other PyV types. This study provides limited evidence that infection with certain PyV s may be related to the occurrence of SCC in the general population of the United States.