Open AccessAssociation between baseline serum glucose, triglycerides and total cholesterol, and prostate cancer risk categories
Author(s) -
Arthur Rhonda,
Møller Henrik,
Garmo Hans,
Holmberg Lars,
Stattin Pår,
Malmstrom Håkan,
Lambe Mats,
Hammar Niklas,
Walldius Göran,
Robinson David,
Jungner Ingmar,
Hemelrijck Mieke Van
Publication year - 2016
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.665
Subject(s) - hypertriglyceridemia , medicine , dyslipidemia , prostate cancer , odds ratio , endocrinology , gastroenterology , cholesterol , logistic regression , diabetes mellitus , cancer , gynecology , oncology , triglyceride
Lifestyle‐related risk factors such as hyperglycemia and dyslipidemia have been associated with several cancers. However, studies exploring their link with prostate cancer ( PC a) clinicopathological characteristics are sparse and inconclusive. Here, we investigated the associations between serum metabolic markers and PCa clinicopathological characteristics. The study comprised 14,294 men from the Swedish Apolipoprotein MOrtality RISk ( AMORIS ) cohort who were diagnosed with PC a between 1996 and 2011. Univariate and multivariable logistic regression were used to investigate the relation between glucose, triglycerides and total cholesterol and PC a risk categories, PSA , Gleason score, and T‐stage. Mean age at time of PC a diagnosis was 69 years. Men with glucose levels >6.9 mmol/L tend to have PSA <4 μ g/L, while those with glucose levels of 5.6–6.9 mmol/L had a greater odds of PSA >20 μ g/L compared to PSA 4.0–9.9 μ g/L. Hypertriglyceridemia was also positively associated with PSA >20 μ g/L. Hyperglycemic men had a greater odds of intermediate‐ and high‐grade PC a and advanced stage or metastatic PC a. Similarly, hypertriglyceridemia was positively associated with high‐grade PC a. There was also a trend toward an increased odds of intermediate risk localized PC a and advanced stage PC a among men with hypertriglyceridemia. Total cholesterol did not have any statistically significant association with any of the outcomes studied. Our findings suggest that high serum levels of glucose and triglycerides may influence PC a aggressiveness and severity. Further investigation on the role of markers of glucose and lipid metabolism in influencing PC a aggressiveness and severity is needed as this may help define important targets for intervention.