Open AccessThe Barrett‐associated variants at GDF 7 and TBX 5 also increase esophageal adenocarcinoma risk
Author(s) -
Becker Jessica,
May Andrea,
Gerges Christian,
Anders Mario,
Schmidt Claudia,
Veits Lothar,
Noder Tania,
Mayershofer Rupert,
Kreuser Nicole,
Manner Hendrik,
Venerito Marino,
Hofer JanHinnerk,
Lyros Orestis,
Ahlbrand Constantin J.,
Arras Michael,
Hofer Sebastian,
Heinrichs Sophie K. M.,
Weise Katharina,
Hess Timo,
Böhmer Anne C.,
Kosiol Nils,
Kiesslich Ralf,
Izbicki Jakob R.,
Hölscher Arnulf H.,
Bollschweiler Elfriede,
Malfertheiner Peter,
Lang Hauke,
Moehler Markus,
Lorenz Dietmar,
Ott Katja,
Schmidt Thomas,
Nöthen Markus M.,
Hackelsberger Andreas,
Schumacher Brigitte,
Pech Oliver,
Vashist Yogesh,
Vieth Michael,
Weismüller Josef,
Knapp Michael,
Neuhaus Horst,
Rösch Thomas,
Ell Christian,
Gockel Ines,
Schumacher Johannes
Publication year - 2016
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.641
Subject(s) - barrett's esophagus , biology , esophagus , esophageal adenocarcinoma , sequence (biology) , dysplasia , genetics , adenocarcinoma , cancer , anatomy
Barrett's esophagus ( BE ) and esophageal adenocarcinoma ( EAC ) represent two stages within the esophagitis‐metaplasia‐dysplasia‐adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants confer risk to different stages of the BE / EAC sequence remains mainly unknown. In this study we analyzed three most recently identified BE variants at the genes GDF 7 (rs3072), TBX 5 (rs2701108), and ALDH 1A2 (rs3784262) separately in BE and EAC samples in order to determine their risk effects during BE / EAC sequence. Our data show that rs3072 at GDF 7 and rs2701108 at TBX 5 are also associated with EAC and conclude that both loci confer disease risk also at later stages of the BE / EAC sequence. In contrast, rs3784262 at ALDH 1A2 was highly significantly associated with BE , but showed no association with EAC . Our data do not provide evidence that the ALDH 1A2 locus confers equal risk in early and late stages of BE / EAC sequence.