Open AccessQuantitative assessment of the association between Fas/FasL gene polymorphism and susceptibility to esophageal carcinoma in a north Chinese population
Author(s) -
Zhang Meijuan,
Wu Cuiping,
Li Baohuan,
Du Wenjun,
Zhang Chuanzhen,
Chen Ziping
Publication year - 2016
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.633
Subject(s) - fas ligand , genotype , carcinoma , han chinese , chinese population , gene , single nucleotide polymorphism , biology , restriction fragment length polymorphism , population , immunology , oncology , medicine , apoptosis , genetics , programmed cell death , environmental health
The case–control study aims to investigate the association of Fas and FasL genetic polymorphisms (Fas‐670A/G (rs1800682), Fas‐1377G/A (rs2234767) and FasL‐844T/C (rs763110)) with esophageal carcinoma susceptibility in a north Chinese population. A total of 204 patients with esophageal carcinoma and 248 healthy controls were enrolled from Henan, China and genotyped by the polymerase chain reaction and restriction fragment length polymorphism method. There were no significant differences in distributions of their genotypes frequencies between patients and controls in Fas‐670A/G, Fas‐1377G/A and FasL‐844T/C polymorphisms ( P > 0.05). Stratified analysis showed that no significant association was found between esophageal carcinoma and gene polymorphisms of Fas‐670 A/G, Fas‐1377G/A, and FasL‐844T/C ( P > 0.05). Genetic polymorphisms in the death pathway genes Fas and FasL were not associated with risk of developing esophageal carcinoma in a north Chinese population.