Open AccessPotentially functional polymorphisms in PAK 1 are associated with risk of lung cancer in a Chinese population
Author(s) -
Zheng Mingfeng,
Liu Jia,
Zhu Meng,
Yin Rong,
Dai Juncheng,
Sun Jie,
Shen Wei,
Ji Yong,
Jin Guangfu,
Ma Hongxia,
Dong Jing,
Xu Lin,
Hu Zhibin,
Shen Hongbing
Publication year - 2015
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.524
Subject(s) - lung cancer , allele , carcinogenesis , genotype , population , cancer , oncology , biology , medicine , case control study , genetics , cancer research , gene , environmental health
P21‐activated kinase 1( PAK 1) plays an important role in the regulation of cell morphogenesis, motility, mitosis, and angiogenesis and has been implicated with tumorigenesis and tumor progression. We hypothesized that functional polymorphisms in PAK 1 gene may modify the risk of lung cancer. We screened four potentially functional polymorphisms (rs2154754, rs3015993, rs7109645, and rs2844337) in PAK 1 gene and evaluated the association between the genetic variants and lung cancer risk in a case – control study including 1341 lung cancer cases and 1982 cancer‐free controls in a Chinese population. We found that variant allele of rs2154754 was significantly associated with a decreased risk of lung cancer ( OR = 0.85, 95% CI: 0.77–0.95, P = 0.004), meanwhile the result of rs3015993 was marginal ( OR = 0.90, 95% CI : 0.81–1.00, P = 0.044). After multiple comparisons, rs2154754 was still significantly associated with the lung cancer risk ( P < 0.0125 for Bonferroni correction). We also detected a significant interaction between rs2154754 genotypes and smoking levels on lung cancer risk ( P = 0.042). Combined analysis of these two polymorphisms showed a significant allele‐dosage association between the number of protective alleles and reduced risk of lung cancer ( P trend = 0.008). These findings indicate that genetic variants in PAK 1 gene may contribute to susceptibility to lung cancer in the Chinese population.