Open AccessHome‐based physical activity after treatment for esophageal cancer—A randomized controlled trial
Author(s) -
Anandavadivelan Poorna,
Malberg Kalle,
Vikstrom Karin,
Nielsen Sandra,
Holdar Ulrika,
Johar Asif,
Lagergren Pernilla
Publication year - 2023
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.5131
Subject(s) - medicine , randomized controlled trial , grip strength , esophageal cancer , physical therapy , muscle strength , confidence interval , cancer , surgery
Abstract Background The treatment of most esophageal cancer patients includes chemo(radio)therapy and extensive surgery, causing physical decline with loss of muscles. This trial aimed to test the hypothesis that a tailored home‐based physical activity (PA) intervention improves muscle strength and mass in patients having undergone curative treatment for esophageal cancer. Methods Patients operated for esophageal cancer 1 year earlier were included in a nationwide randomized controlled trial in Sweden in 2016–2020. The intervention group was randomized to a 12‐week home‐based exercise program, while the control group was encouraged to maintain routine daily PA. The primary outcomes were changes in maximal/average hand grip strength measured with hand grip dynamometer and lower extremity strength measured using 30‐second chair stand test and muscle mass measured using a portable bio‐impedance analysis monitor. Intention‐to‐treat analysis was used, and results were presented as mean differences (MDs) with 95% confidence intervals (CIs). Results Among 161 randomized patients, 134 completed the study, 64 in the intervention group and 70 in the control group. Compared with the control group (MD 2.73; 95% CI 1.75–3.71), patients in the intervention group (MD 4.48; 95% CI 3.18–5.80) had statistically significantly ( p = 0.03) improved lower extremity strength. No differences were seen for hand grip strength or muscle mass. Conclusion A home‐based PA intervention 1 year after surgery for esophageal cancer improves lower extremity muscle strength.