Open AccessMolecular subtypes predict second breast events of ductal carcinoma in situ after breast‐conserving surgery
Author(s) -
Yang Yilan,
Zhao Xu,
Wang Xuanyi,
Jin Kairui,
Luo Jurui,
Yang Zhaozhi,
Mei Xin,
Ma Jinli,
Shao Zhimin,
Zhang Zhen,
Chen Xingxing,
Guo Xiaomao,
Yu Xiaoli
Publication year - 2022
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.4651
Subject(s) - breast cancer , ductal carcinoma , medicine , oncology , proportional hazards model , incidence (geometry) , univariate analysis , breast conserving surgery , multivariate analysis , cumulative incidence , in situ , biology , cancer , mastectomy , cohort , physics , meteorology , optics
Purpose Currently, the prognostic value of molecular subtypes in ductal carcinoma in situ (DCIS) remains unclear. In this study, we explored whether molecular subtypes could predict second breast events (SBEs) in patients after breast‐conserving surgery (BCS). Methods From January 2008 to December 2016, 291 DCIS patients treated with BCS were retrospectively analyzed. Patients were classified into four molecular subtypes: luminal A, luminal B, human epidermal growth factor receptor 2 (HER2) overexpression, and triple‐negative breast cancer (TNBC). The SBE incidence was calculated by the competing risk model and compared by Gray's test. The disease‐free survival rates were estimated by the Kaplan–Meier method and compared by the log‐rank test. Prognostic factors were evaluated by univariate and multivariate COX proportional hazards regression model. Results With a median follow‐up of 66 months, 12 SBEs were identified. The 5‐year overall SBE incidence of luminal A, luminal B, HER2 overexpression, and TNBC was 2.18%, 4.25%, 15.15%, and 0.00%, respectively. In the univariate analysis, the HER2 overexpression subtype was the predictor of overall ( p = 0.005), in situ ( p = 0.004), and ipsilateral SBEs ( p = 0.008). Patients with endocrine therapy were less likely to develop in situ SBEs ( p = 0.039). Additionally, patients with closed (<2 mm) or involved margins were related to a higher risk of contralateral SBEs ( p = 0.029). In the multivariate analysis, the HER2 overexpression subtype remained of prognostic values for overall ( p = 0.006), in situ ( p = 0.029), and ipsilateral SBEs ( p = 0.012). Conclusions The molecular subtype, especially the HER2 overexpression subtype, was the independent prognostic factor for DCIS patients who underwent BCS.