Open AccessThe role of mesenchymal stem cells in the occurrence, development, and therapy of hepatocellular carcinoma
Author(s) -
Zhang Xiaoli,
Li Na,
Zhu Ying,
Wen Wei
Publication year - 2022
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.4521
Subject(s) - mesenchymal stem cell , hepatocellular carcinoma , cancer research , tumor microenvironment , cancer stem cell , stem cell , liver cancer , medicine , cancer , biology , tumor cells , pathology , microbiology and biotechnology
Hepatocellular carcinoma (HCC) is the most common type of liver malignant tumor, with high recurrence and mortality rates. Mesenchymal stem cells (MSCs) are multipotent cells that can be recruited into the tumor microenvironment (TME). What is known, TME plays a vital part in tumor progression. In recent years, accumulating studies have found that MSCs have a dual role of promotion and inhibition in the occurrence and development of HCC. In this review, we analyzed the role of MSCs in TME and summarized the relationship between MSCs and liver cancer stem cells, the molecular signaling pathway mechanisms of MSCs promoting and inhibiting HCC, and the latest research progress of MSCs in the treatment of HCC.