z-logo
open-access-imgOpen Access
Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain
Author(s) -
FriasGomez Jon,
Tovar Eva,
Vidal August,
Murgui Lluis,
Ibáñez Raquel,
PeremiquelTrillas Paula,
Paytubi Sonia,
Baixeras Nuria,
Zanca Alba,
Ponce Jordi,
Pineda Marta,
Brunet Joan,
de Sanjosé Silvia,
Bosch Francesc Xavier,
MatiasGuiu Xavier,
Alemany Laia,
Costas Laura
Publication year - 2021
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.4217
Subject(s) - medicine , cytology , endometrial cancer , cervical cancer , gynecology , atypia , colposcopy , cancer , obstetrics , pathology
Cervical cytology is a well‐stablished cervical cancer screening method. However, due to the anatomical continuity of the genital tract, it can also detect signs of endometrial disease. Our aim was to estimate the sensitivity of cervical cytology in endometrial cancer detection and prognosis in a large population over a 30‐year period in a large academic tertiary hospital in Spain. Methodology We performed a search for women diagnosed with endometrial cancer from 1990 to 2020, who were surgically treated and had a previous cervical cytology result. Information Technologies Department databases from Bellvitge University Hospital and the Screenwide case–control study's database were used. Cervical cytology results were classified as abnormal when squamous lesions, glandular atypia or malignant cells were identified. Results Overall, we evaluated 371 women with endometrial cancer and a documented cervical cytology performed within 3 years previous to surgical treatment. Overall, the sensitivity of cervical cytology for endometrial cancer detection was 25.6%. Several clinico‐pathological characteristics, such as non‐endometrioid histology and a higher stage, were correlated with higher sensitivity. Discussion We observed a low sensitivity of cervical cytology to effectively diagnose endometrial cancer. However, recent technological advances using genomics and epigenomics may offer a promising perspective to detect endometrial cancer with high sensitivity in these cervical specimens.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here