Open AccessComprehensive analysis of a new prognosis signature based on histone deacetylases in clear cell renal cell carcinoma
Author(s) -
Cheng Fajuan,
Zheng Bin,
Wang Jianwei,
Zhao Guiting,
Yao Zhongshun,
Niu Zhihong,
He Wei
Publication year - 2021
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.4156
Subject(s) - clear cell renal cell carcinoma , hdac10 , hdac8 , histone , cancer research , carcinogenesis , biology , renal cell carcinoma , proteomics , hdac11 , histone deacetylase , transcriptome , computational biology , cancer , bioinformatics , genetics , medicine , oncology , gene , gene expression
Histone deacetylases (HDAC) family is vital for tumorigenesis and tumor progression. However, the exact role of the HDAC family in clear cell renal cell carcinoma (ccRCC) remains unclear. Based on The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), and The Human Protein Atlas (HPA) database, we investigated and validated the expression profile, clinical significance and prognostic value of HDAC family members in ccRCC. Moreover, we further explored the correlation between HDACs and tumor microenvironment, tumor stemness, drug activity and immune subtype. The HDAC8 , HDAC10, and HDAC11 manifested potential clinical value for prognosis, and the correlation analyses reveals underlying molecular mechanisms, which deserve further investigation for ccRCC. This Integrated bioinformatics analysis, based on transcriptomics and proteomics, implied that HDAC8 , HDAC10, and HDAC11 may serve as potential molecular biomarkers and therapeutic targets for ccRCC, but some underlying molecular mechanisms still need to be elucidated.