Open AccessCardiovascular disease risks in younger versus older adult B‐cell non‐Hodgkin’s lymphoma survivors
Author(s) -
Ocier Krista,
Abdelaziz Sarah,
Kim Seungmin,
Rowe Kerry,
Snyder John,
Deshmukh Vikrant,
Newman Michael,
Fraser Alison,
Smith Ken,
Porucznik Christina A.,
Shoaf Kimberley,
Stanford Joseph B.,
Lee Catherine J.,
Hashibe Mia
Publication year - 2021
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.3934
Subject(s) - disease , medicine , hodgkin lymphoma , lymphoma , young adult , pediatrics , gerontology , oncology
Young cancer survivors may be at increased risk of early‐onset chronic health conditions. The aim of this population‐based study is to estimate cardiovascular disease (CVD) risk among younger versus older B‐cell non‐Hodgkin's lymphoma (B‐NHL) survivors compared with their respective general population cohorts. Methods B‐NHL survivors diagnosed from 1997 to 2015 in the Utah Cancer Registry were matched with up to five cancer‐free individuals on birth year, sex, and birth state, using the statewide Utah Population Database. Electronic medical records and statewide health care facility data were used to identify disease outcomes ≥5 years after cancer diagnosis. Cox Proportional Hazards models were used to estimate hazard ratios for B‐NHL survivors diagnosed at <65 years and ≥65 years old. Results Younger B‐NHL survivors had higher relative risks than older cancer survivors of chronic rheumatic disease of the heart valves (HR = 4.14, 99% CI = 2.17–7.89; P value heterogeneity = 0.004); peri‐, endo‐, and myocarditis (HR = 2.43, 99% CI = 1.38–4.28; P value heterogeneity = 0.016); diseases of the arteries (HR = 1.63, 99% CI = 1.21–2.21; P value heterogeneity = 0.044); and hypotension (HR = 2.44, 99% CI = 1.58–3.75; P value heterogeneity = 0.048). B‐NHL survivors of both age groups had elevated relative risks of heart disease overall and congestive heart failure. Conclusion Younger B‐NHL survivors had higher risks than older B‐NHL survivors of specific cardiovascular diseases compared to their respective general population cohorts.