Open AccessTransoral surgery for superficial head and neck cancer: National Multi‐Center Survey in Japan
Author(s) -
Katada Chikatoshi,
Muto Manabu,
Fujii Satoshi,
Yokoyama Tetsuji,
Yano Tomonori,
Watanabe Akihito,
Iizuka Toshiro,
Yoshinaga Shigetaka,
Tateya Ichiro,
Mitani Hiroki,
Shimizu Yuichi,
Takahashi Akiko,
Kamijo Tomoyuki,
Hanaoka Noboru,
Abe Makoto,
Shiotani Akihiro,
Kano Koichi,
Asada Yukinori,
Matsuhashi Tamotsu,
Umeno Hirohito,
Okami Kenji,
Goda Kenichi,
Hori Shinichiro,
Ono Yoichiro,
Terai Shuji,
Nagami Yasuaki,
Takemura Kenichi,
Kawada Kenro,
Ando Mizuo,
Shimeno Naoto,
Arai Akihito,
Sakamoto Yasutoshi,
Ichinoe Masaaki,
Nemoto Tetsuo,
Fujita Masahiro,
Watanabe Hidenobu,
Shimoda Tadakazu,
Ochiai Atsushi,
Kato Takakuni,
Hayashi Ryuichi
Publication year - 2021
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.3927
Subject(s) - medicine , surgery , larynx , head and neck cancer , transoral robotic surgery , incidence (geometry) , adverse effect , pathological , cancer , radiation therapy , physics , optics
Head and neck cancers, especially in hypopharynx and oropharynx, are often detected at advanced stage with poor prognosis. Narrow band imaging enables detection of superficial cancers and transoral surgery is performed with curative intent. However, pathological evaluation and real‐world safety and clinical outcomes have not been clearly understood. The aim of this nationwide multicenter study was to investigate the safety and efficacy of transoral surgery for superficial head and neck cancer. We collected the patients with superficial head and neck squamous cell carcinoma who were treated by transoral surgery from 27 hospitals in Japan. Central pathology review was undertaken on all of the resected specimens. The primary objective was effectiveness of transoral surgery, and the secondary objective was safety including incidence and severity of adverse events. Among the 568 patients, a total of 662 lesions were primarily treated by 575 sessions of transoral surgery. The median tumor diameter was 12 mm (range 1–75) endoscopically. Among the lesions, 57.4% were diagnosed as squamous cell carcinoma in situ . The median procedure time was 48 minutes (range 2–357). Adverse events occurred in 12.7%. Life‐threatening complications occurred in 0.5%, but there were no treatment‐related deaths. During a median follow‐up period of 46.1 months (range 1–113), the 3‐year overall survival rate, relapse‐free survival rate, cause‐specific survival rate, and larynx‐preservation survival rate were 88.1%, 84.4%, 99.6%, and 87.5%, respectively. Transoral surgery for superficial head and neck cancer offers effective minimally invasive treatment. Clinical trials registry number: UMIN8276.