Open AccessHepatocyte nuclear factor 1 beta: A perspective in cancer
Author(s) -
Chandra Shubhra,
Srinivasan Srilakshmi,
Batra Jyotsna
Publication year - 2021
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.3676
Subject(s) - hepatocyte nuclear factors , hnf1b , transcription factor , endometrial cancer , biology , hepatocyte nuclear factor 4 , homeobox , prostate cancer , hnf1a , cancer research , hepatocyte , cancer , diabetes mellitus , gene , endocrinology , genetics , nuclear receptor , in vitro
Hepatocyte nuclear factor 1 beta (HNF1 β/B) exists as a homeobox transcription factor having a vital role in the embryonic development of organs mainly liver, kidney and pancreas. Initially described as a gene causing maturity‐onset diabetes of the young (MODY), HNF1β expression deregulation and single nucleotide polymorphisms in HNF1β have now been associated with several tumours including endometrial, prostate, ovarian, hepatocellular, renal and colorectal cancers. Its function has been studied either as homodimer or heterodimer with HNF1α . In this review, the role of HNF1B in different cancers will be discussed along with the role of its splice variants, and its emerging role as a potential biomarker in cancer.