Open AccessStereotactic body radiotherapy vs conventionally fractionated chemoradiation in locally advanced pancreatic cancer: A multicenter case‐control study (PAULA‐1)
Author(s) -
Arcelli Alessandra,
Buwenge Milly,
Macchia Gabriella,
Bertini Federica,
Guido Alessandra,
Deodato Francesco,
Cilla Savino,
Scotti Valerio,
Rosetto Maria Elena,
Djan Igor,
Parisi Salvatore,
Mattiucci Gian Carlo,
Cellini Francesco,
Fiore Michele,
Bonomo Pierluigi,
Belgioia Liliana,
Niespolo Rita Marina,
Gabriele Pietro,
Di Marco Mariacristina,
Simoni Nicola,
Mazzarotto Renzo,
Morganti Alessio Giuseppe
Publication year - 2020
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.3330
Subject(s) - medicine , cohort , pancreatic cancer , stage (stratigraphy) , toxicity , radiation therapy , radiosurgery , oncology , nuclear medicine , progression free survival , overall survival , urology , cancer , paleontology , biology
Conventionally fractionated chemoradiation (CRT) or chemotherapy (CHT) are considered as standard options in locally advanced pancreatic cancer (LAPC) while stereotactic body radiotherapy (SBRT) is an emerging treatment in this setting. The aim of this study was to compare two cohorts of LAPC patients treated with SBRT ± CHT vs CRT ± CHT in terms of local control (LC), distant metastases‐free survival (DMFS), progression‐free survival (PFS), overall survival (OS), and toxicity. Eighty patients were included. Patients in the two cohorts were matched according to: age ≤/>65 years, tumor diameter (two cut‐offs: