Open AccessEfficacy and safety of carbon‐ion radiotherapy for the malignant melanoma: A systematic review
Author(s) -
Li Chengcheng,
Zhang Qiuning,
Li Zheng,
Feng Shuangwu,
Luo Hongtao,
Liu Ruifeng,
Wang Lina,
Geng Yichao,
Zhao Xueshan,
Yang Zhen,
Li Qiang,
Yang Kehu,
Wang Xiaohu
Publication year - 2020
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.3134
Subject(s) - carbon ion radiotherapy , medicine , radiation therapy , oncology , melanoma , overall survival , surgery , cancer research
Malignant melanomas (MMs) were the fifth most common cancer in men and the sixth most common cancer in women in 2018, respectively. These are characterized by high metastatic rates and poor prognoses. We systematically reviewed safety and efficacy of carbon‐ion radiotherapy (CIRT) for treating MMs. Eleven studies were eligible for review, and the data showed that MM patients showed better local control with low recurrence and mild toxicities after CIRT. Survival rates were slightly higher in patients with cutaneous or uveal MMs than in those with mucosal MMs. CIRT in combination with chemotherapy produced higher progression‐free survival rates than CIRT only. In younger patients, higher rates of distant metastases of gynecological MMs were observed. The data indicated that CIRT is effective and safe for treating MMs; however, a combination with systemic therapy is recommended to ensure the best possible prognosis for MMs.