Open AccessChemokines and chemokine receptors: A new strategy for breast cancer therapy
Author(s) -
Liu Hui,
Yang Zhenjiang,
Lu Wenping,
Chen Zhen,
Chen Lianyu,
Han Shuyan,
Wu Xiaoyu,
Cai Tiange,
Cai Yu
Publication year - 2020
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.3014
Subject(s) - ccr10 , chemokine receptor , chemokine , ccl7 , ccl13 , ccr1 , cxc chemokine receptors , ccl21 , angiogenesis , cancer research , immunology , ccl18 , biology , inflammation
Chemokines and chemokine receptors not only participate in the development of tissue differentiation, hematopoiesis, inflammation, and immune regulation but also play an important role in the process of tumor development. The role of chemokines and chemokine receptors in tumors has been emphasized in recent years. More and more studies have shown that chemokines and chemokine receptors are closely related to the occurrence, angiogenesis, metastasis, drug resistance, and immunity of breast cancer. Here, we review recent progression on the roles of chemokines and chemokine receptors in breast cancer, and discuss the possible mechanism in breast cancer that might facilitate the development of new therapies by targeting chemokines as well as chemokine receptors. Chemokines and chemokine receptors play an important role in the occurrence and development of breast cancer. In‐depth study of chemokines and chemokine receptors can provide intervention targets for breast cancer biotherapy. The regulation of chemokines and chemokine receptors may become a new strategy for breast cancer therapy.