Open AccessMicroRNA‐320a inhibits invasion and metastasis in osteosarcoma by targeting cytoplasmic polyadenylation element‐binding protein 1
Author(s) -
Wang Yanlong,
Yang Jiyu,
Chen Pangtao,
Song Yu,
An Weizheng,
Zhang Haoran,
Butegeleqi Butegeleqi,
Yan Jinglong
Publication year - 2020
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.2919
Subject(s) - osteosarcoma , gene knockdown , cancer research , microrna , suppressor , metastasis , three prime untranslated region , medicine , biology , cancer , untranslated region , apoptosis , messenger rna , gene , biochemistry
Osteosarcoma is a primary malignant bone tumor, which affects children, adolescents, and young adults commonly. MicroRNAs (miRNAs) have been proved to be dysregulated in different cancers, including osteosarcoma. Although miR‐320a has been implicated in many types of malignancies, little is known about the role of miR‐320a in osteosarcoma. In this study, we show that the overexpression of miR‐320a or knockdown of cytoplasmic polyadenylation element‐binding protein 1 (CPEB1) inhibited osteosarcoma cell migration and invasion. miR‐320a downregulates CPEB1 expression by directly targeting the CPEB1 3′‐UTR. Furthermore, CPEB1 reintroduction reversed the antiproliferation, antimigration, and antiinvasion roles of miR‐320a, indicating that miR‐320a might function as a tumor suppressor in osteosarcoma through CPEB1. In conclusion, our study demonstrates that miR‐320a plays a critical role in osteosarcoma progression and may provide a potential therapeutic target for osteosarcoma.