Open AccessGenetic association analysis identifies a role for ANO5 in prostate cancer progression
Author(s) -
Yu ChiaCheng,
Chen LihChyang,
Huang ChaoYuan,
Lin Victor C.,
Lu TeLing,
Lee ChengHsueh,
Huang ShuPin,
Bao BoYing
Publication year - 2020
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.2909
Subject(s) - prostate cancer , single nucleotide polymorphism , breakpoint cluster region , allele , medicine , biochemical recurrence , prostate , prostatectomy , cancer , gene , oncology , cancer research , biology , genetics , genotype
Anoctamins were originally identified as a family of calcium‐activated chloride channels, but recently their roles in the development of different types of malignancies were suggested. Here, we evaluated the associations between 211 common single‐nucleotide polymorphisms in 10 anoctamin genes with biochemical recurrence (BCR) after radical prostatectomy (RP) for localized prostate cancer. Four SNPs ( ANO4 rs585335, AN O5 rs4622263, ANO7 rs62187431, and ANO10 rs118005571) remained significantly associated with BCR after multiple test correction ( P < .05 and q = 0.232) and adjustment for known prognostic factors. Expression quantitative trait loci analysis found that ANO5 rs4622263 C and ANO10 rs118005571 C alleles were associated with decreased mRNA expression levels. Moreover, lower expression of ANO5 was correlated with more advanced tumors and poorer outcomes in two independent prostate cancer cohorts. Taken together, ANO5 rs4622263 was associated with BCR, and ANO5 gene expression was correlated with patient prognosis, suggesting a pivotal role for ANO5 in prostate cancer progression.