Open AccessRace, tumor location, and disease progression among low‐risk prostate cancer patients
Author(s) -
Mygatt Justin G.,
Cullen Jennifer,
Streicher Samantha A.,
Kuo HuaiChing,
Chen Yongmei,
Young Denise,
Gesztes William,
Williams Grant,
Conti Galen,
Porter Christopher,
Stroup Sean P.,
Rice Kevin R.,
Rosner Inger L.,
Burke Allen,
Sesterhenn Isabell
Publication year - 2020
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.2864
Subject(s) - medicine , prostate cancer , biochemical recurrence , proportional hazards model , oncology , prostatectomy , cohort , cancer , survival analysis , retrospective cohort study , veterans affairs , urology
Abstract Background The relationship between race, prostate tumor location, and BCR‐free survival is inconclusive. This study examined the independent and joint roles of patient race and tumor location on biochemical recurrence‐free (BCR) survival. Methods A retrospective cohort study was conducted among men with newly diagnosed, biopsy‐confirmed, NCCN‐defined low risk CaP who underwent radical prostatectomy (RP) at the Walter Reed National Military Medical Center from 1996 to 2008. BCR‐free survival was modeled using Kaplan‐Meier estimation curves and multivariable Cox proportional hazards (PH) analyses. Results There were 539 eligible patients with low‐risk CaP (25% African American, AA; 75% Caucasian American, CA). Median age at CaP diagnosis and post‐RP follow‐up time was 59.2 and 8.1 years, respectively. Kaplan‐Meier analyses showed no significant association between race ( P = .52) or predominant tumor location ( P = .98) on BCR‐free survival. In Cox PH multivariable analysis, neither race (HR = 1.18; 95% CI = 0.68‐2.02; P = .56) nor predominant tumor location (HR = 1.13; 95% CI = 0.59‐2.15; P = .71) was an independent predictor of BCR‐free survival. Conclusions Neither race nor predominant tumor location was associated with adverse oncologic outcome.