Open AccessRisk of squamous cell skin cancer after organ transplant associated with antibodies to cutaneous papillomaviruses, polyomaviruses, and TMC6/8 (EVER1/2) variants
Author(s) -
Madeleine Margaret M.,
Carter Joseph J.,
Johnson Lisa G.,
Wipf Gregory C.,
Davis Connie,
Berg Daniel,
Nelson Karen,
Daling Janet R.,
Schwartz Stephen M.,
Galloway Denise A.
Publication year - 2014
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.280
Subject(s) - skin cancer , squamous cell cancer , antibody , organ transplantation , medicine , merkel cell polyomavirus , virology , dermatology , cancer , pathology , transplantation , immunology , merkel cell carcinoma , carcinoma
Squamous cell skin cancer ( SCSC ) disproportionately affects organ transplant recipients, and may be related to increased viral replication in the setting of immune suppression. We conducted a nested case–control study among transplant recipients to determine whether SCSC is associated with antibodies to cutaneous human papillomaviruses ( HPV ), to genes associated with a rare genetic susceptibility to HPV ( TMC 6/ TMC 8 ), or to human polyomaviruses ( HP yV). Cases ( n = 149) had histologically confirmed SCSC , and controls ( n = 290) were individually matched to cases on time since transplant, type of transplant, gender, and race. All subjects had serum drawn immediately prior to transplant surgery. Antibodies to 25 cutaneous HPV s and six HP yVs were assayed by detection of binding to virus‐like particles, and 11 TMC 6/8 variants were genotyped. After correction for multiple comparisons, only antibodies to HPV 37 were associated with SCSC ( OR 2.0, 95% CI 1.2–3.4). Common genetic variants of TMC 6/8 were not associated with SCSC , but three variants in TMC 8 (rs12452890, rs412611, and rs7208422) were associated with greater seropositivity for species 2 betapapillomaviruses among controls. This study suggests that some beta HPV s, but not polyomaviruses, may play a role in the excess risk of SCSC among transplant recipients.