Open AccessEffects of different doses of erythropoietin in patients with myelodysplastic syndromes: A propensity score‐matched analysis
Author(s) -
Balleari Enrico,
Filiberti Rosa Angela,
Salvetti Chiara,
Allione Bernardino,
Angelucci Emanuele,
Bruzzone Marco,
Calzamiglia Tullio,
Cavaliere Marina,
Cavalleri Maurizio,
Cilloni Daniela,
Clavio Marino,
Crisà Elena,
Da Col Anna,
Danise Paolo,
Pilo Federica,
Ferrero Dario,
Finelli Carlo,
Gioia Daniela,
Lemoli Roberto Massimo,
Masiera Elisa,
Messa Emanuela,
Miglino Maurizio,
Musto Pellegrino,
Natalie Oliva Esther,
Poloni Antonella,
Salvi Flavia,
Sanna Alessandro,
Scudeletti Marco,
Tassara Rodolfo,
Santini Valeria
Publication year - 2019
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.2638
Subject(s) - medicine , erythropoietin , myelodysplastic syndromes , anemia , propensity score matching , gastroenterology , hemoglobin , international prognostic scoring system , univariate analysis , subgroup analysis , multivariate analysis , erythropoiesis , cohort , confidence interval , bone marrow
Background Erythropoiesis‐stimulating agents effectively improve the hemoglobin levels in a fraction of anemic patients with myelodysplastic syndromes (MDS). Higher doses (HD) of recombinant human erythropoietin (rhEPO) have been proposed to overcome suboptimal response rates observed in MDS patients treated with lower “standard doses” (SD) of rhEPO. However, a direct comparison between the different doses of rhEPO is lacking. Methods A cohort of 104 MDS patients treated with HD was retrospectively compared to 208 patients treated with SD in a propensity score‐matched analysis to evaluate hematological improvement‐erythroid (HI‐E) rate induced by the different doses of rhEPO. The impact of rhEPO doses on survival and progression to leukemia was also investigated. Results Overall HI‐E rate was 52.6%. No difference was observed between different rhEPO doses ( P = .28) in matched cohorts; in a subgroup analysis, transfusion‐dependent patients and patients with higher IPSS‐R score obtained a higher HI‐E rate with HD, although without significant impact on overall survival (OS). Achievement of HI‐E resulted in superior OS. At univariate analysis, a higher HI‐E rate was observed in transfusion‐independent patients ( P < .001), with a lower IPSS‐R score ( P < .001) and lower serum EPO levels ( P = .027). Multivariate analysis confirmed that rhEPO doses were not significantly related to HI‐E ( P = .26). There was no significant difference in OS or progression to leukemia in patients treated with HD vs SD. Conclusion SD are substantially equally effective to HD to improve anemia and influencing survival in MDS patients stratified according to similar propensity to be exposed to rhEPO treatment.